8 - 10 Finally, visual field loss correlated with RNFL thickness as determined by this OCT prototype in glaucomatous eyes. 7 Reproducibility studies using an OCT prototype have shown SDs of measurement of RNFL and retinal thicknesses of approximately 10 to 20 µm (10%-20%) in normal and glaucomatous eyes. 6 This instrument also performed well in detecting induced RNFL lesions in monkeys. 3, 5 With a prototype instrument, OCT data were reported to correlate with the known topography of human retinas. 2 - 4 Optical coherence tomography has been demonstrated to detect changes in tissue thickness with micrometer-scale sensitivity. 1 Early biological uses of this technology involved imaging of the human anterior chamber, peripapillary retina, and coronary artery. This technology was initially designed for fiberoptic use. OPTICAL COHERENCE tomography (OCT) is one promising technology that has been developed to assess tissue thickness in vivo, such as that of the retinal nerve fiber layer (RNFL). Retinal nerve fiber layer was significantly thinner in glaucomatous eyes than in ocular hypertensive and normal eyes throughout 360° and in all quadrants.Ĭonclusion These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes. More specifically, RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes in the inferior quadrant, 84.8 µm (75.6-94.0 µm) vs 107.6 µm (99.3-115.9 µm) and in the nasal quadrant, 44.1 µm (37.5-51.7 µm) vs 61.8 µm (53.0-65.6 µm). Results Mean (95% confidence interval) RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes, 72.8 µm (66.4-78.1 µm) and 85.8 µm (80.2-91.7 µm), respectively. A single index of average RNFL thickness throughout 360° also was obtained. In each eye, average RNFL thickness measurements were obtained in temporal, superior, nasal, and inferior quadrants. ![]() Three circular scans were obtained for each eye at a diameter of 3.4 mm around the optic disc. Subject eyes were classified into diagnostic groups based on intraocular pressure, stereoscopic disc photographs, and standard automated perimetry. Methods The mean RNFL thickness of ocular hypertensive (n = 28) eyes was compared with age-matched normal (n = 30) and glaucomatous (n = 29) eyes. Objective To quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in ocular hypertensive eyes with normal and glaucomatous eyes using the Optical Coherence Tomograph (OCT 2000, software version A4X1 Humphrey Instruments, San Leandro, Calif). ![]() Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.The values presented herein can be used as a standard with which to compare those of children suspected of having retinal or optic nerve abnormalities.Ĭopyright © 2013 Elsevier Inc. Pediatric means and normative reference ranges are provided for each measurement. SD OCT can be used to assess peripapillary RNFL thickness, macular thickness, and retinal layer thickness in children as young as 5 years. While the thickness of most retinal layers was comparable with those of adults, the outer segment layer was 36% thinner in children than in adults. Peripapillary RNFL thickness was thicker than has been reported in adults, particularly the superior and inferior sectors, and central subfield macular thickness was significantly correlated with age. Thicknesses of individual retinal layers and layer combinations were assessed using custom software to segment the line scans obtained with the Spectralis SD OCT.Īverage global peripapillary RNFL thickness was 107.6 ± 1.2 μm and average central subfield macular thickness was 271.2 ± 2.0 μm. Peripapillary RNFL thickness and macular thickness were assessed for 1 eye of each child using the Heidelberg Spectralis SD OCT software. Imaging was accomplished with the Spectralis SD OCT. ![]() This institutional study enrolled 83 healthy children (aged 5-15 years) as volunteer research subjects at the Retina Foundation of the Southwest (Dallas, Texas) all had normal visual acuity. To establish a normative database of peripapillary retinal nerve fiber layer (RNFL) thickness, macular thickness, and retinal layer thickness in healthy North American children, using spectral-domain optical coherence tomography (SD OCT).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |